Virtual glioblastoma: growth, migration and treatment in a three‐dimensional mathematical model

Steffen E. Eikenberry, Tejas Sankar, Mark C. Preul, Eric J. Kostelich, Craig J. Thalhauser, Yang Kuang

Type: Article

Publication Date: 2009-05-29

Citations: 81

DOI: https://doi.org/10.1111/j.1365-2184.2009.00613.x

Abstract

Glioblastomas are aggressive primary brain cancers that are characterized by extensive infiltration into the brain and are highly resistant to treatment. Through mathematical modelling, we model the process of invasion and predict the relative importance of mechanisms contributing to malignant invasion. Clinically, we predict patterns of tumour recurrence following various modes of therapeutic intervention.

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