Language model driven: a PROTAC generation pipeline with dual
constraints of structure and property
Language model driven: a PROTAC generation pipeline with dual
constraints of structure and property
The imperfect modeling of ternary complexes has limited the application of computer-aided drug discovery tools in PROTAC research and development. In this study, an AI-assisted approach for PROTAC molecule design pipeline named LM-PROTAC was developed, which stands for language model driven Proteolysis Targeting Chimera, by embedding a transformer-based generative model …