Unlocking Potential Binders: Multimodal Pretraining DEL-Fusion for
Denoising DNA-Encoded Libraries
Unlocking Potential Binders: Multimodal Pretraining DEL-Fusion for
Denoising DNA-Encoded Libraries
In the realm of drug discovery, DNA-encoded library (DEL) screening technology has emerged as an efficient method for identifying high-affinity compounds. However, DEL screening faces a significant challenge: noise arising from nonspecific interactions within complex biological systems. Neural networks trained on DEL libraries have been employed to extract compound features, …