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Pinpointing Important Genetic Variants via A Feature-level Filter and Group Knockoffs

Pinpointing Important Genetic Variants via A Feature-level Filter and Group Knockoffs

Identifying variants that carry substantial information on the trait of interest remains a core topic in genetic studies. In analyzing the EADB-UKBB dataset to identify genetic variants associated with Alzheimer's disease (AD), however, we recognize that both existing marginal association tests and conditional independence tests using knockoffs suffer either power …