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A Review of EMA Public Assessment Reports where Non-Proportional Hazards were Identified

A Review of EMA Public Assessment Reports where Non-Proportional Hazards were Identified

While well-established methods for time-to-event data are available when the proportional hazards assumption holds, there is no consensus on the best approach under non-proportional hazards. A wide range of parametric and non-parametric methods for testing and estimation in this scenario have been proposed. In this review we identified EMA marketing …