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The edge of discovery: Controlling the local false discovery rate at the margin

The edge of discovery: Controlling the local false discovery rate at the margin

Despite the popularity of the false discovery rate (FDR) as an error control metric for large-scale multiple testing, its close Bayesian counterpart the local false discovery rate (lfdr), defined as the posterior probability that a particular null hypothesis is false, is a more directly relevant standard for justifying and interpreting …