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Evaluation of mean shift, ComBat, and CycleGAN for harmonizing brain connectivity matrices across sites

Evaluation of mean shift, ComBat, and CycleGAN for harmonizing brain connectivity matrices across sites

Connectivity matrices derived from diffusion MRI (dMRI) provide an interpretable and generalizable way of understanding the human brain connectome. However, dMRI suffers from inter-site and between-scanner variation, which impedes analysis across datasets to improve robustness and reproducibility of results. To evaluate different harmonization approaches on connectivity matrices, we compared graph …