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Lightning-fast adaptive immune receptor similarity search by symmetric deletion lookup

Lightning-fast adaptive immune receptor similarity search by symmetric deletion lookup

An individual's adaptive immune receptor (AIR) repertoire records immune history due to the exquisite antigen specificity of AIRs. Reading this record requires computational approaches for inferring receptor function from sequence, as the diversity of possible receptor-antigen pairs vastly outstrips experimental knowledge. Identification of AIRs with similar sequence and thus putatively …