Antigenic drift and subtype interference shape A(H3N2) epidemic dynamics in the United States
Antigenic drift and subtype interference shape A(H3N2) epidemic dynamics in the United States
Influenza viruses continually evolve new antigenic variants, through mutations in epitopes of their major surface proteins, hemagglutinin (HA) and neuraminidase (NA). Antigenic drift potentiates the reinfection of previously infected individuals, but the contribution of this process to variability in annual epidemics is not well understood. Here, we link influenza A(H3N2) …