Surrogacy validation for time‐to‐event outcomes with illness‐death frailty models
Surrogacy validation for time‐to‐event outcomes with illness‐death frailty models
Abstract A common practice in clinical trials is to evaluate a treatment effect on an intermediate outcome when the true outcome of interest would be difficult or costly to measure. We consider how to validate intermediate outcomes in a causally‐valid way when the trial outcomes are time‐to‐event. Using counterfactual outcomes, …