Guidelines for Evaluating the Comparability of Down-Sampled GWAS Summary Statistics
Guidelines for Evaluating the Comparability of Down-Sampled GWAS Summary Statistics
Proprietary genetic datasets are valuable for boosting the statistical power of genome-wide association studies (GWASs), but their use can restrict investigators from publicly sharing the resulting summary statistics. Although researchers can resort to sharing down-sampled versions that exclude restricted data, down-sampling reduces power and might change the genetic etiology of …