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Challenging age-structured and first order transition cell cycle models of cell proliferation

Challenging age-structured and first order transition cell cycle models of cell proliferation

Abstract Uncontrolled cell proliferation is the key feature of tumours. Because experimental measures provide only a partial view to the underlying proliferative processes, such as cell cycling, cell quiescence and cell death, mathematical modelling aims to provide a unifying view of the data with a quantitative description of the contributing …