Unsupervised Particle Sorting for Cryo-EM using Probabilistic PCA
Unsupervised Particle Sorting for Cryo-EM using Probabilistic PCA
Single-particle cryo-electron microscopy (cryo-EM) is a leading technology to resolve the structure of molecules. Early in the process, the user detects potential particle images in the raw data. Typically, there are many false detections as a result of high levels of noise and contamination. Currently, removing the false detections requires …