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Persistence of immunological memory as a potential correlate of long-term, vaccine-induced protection against Ebola virus disease in humans
Introduction In the absence of clinical efficacy data, vaccine protective effect can be extrapolated from animals to humans, using an immunological biomarker in humans that correlates with protection in animals, in a statistical approach called immunobridging. Such an immunobridging approach was previously used to infer the likely protective effect of …