Adaptive Multiple Comparison Sequential Design (AMCSD) for clinical trials
Adaptive Multiple Comparison Sequential Design (AMCSD) for clinical trials
We propose an adaptive sequential testing procedure for clinical trials that test the efficacy of multiple treatment options, such as dose/regimen, different drugs, sub-populations, endpoints, or a mixture of them in one trial. At any interim analyses, sample size re-estimation can be conducted, and any option can be dropped for …