Classical structural identifiability methodology applied to low-dimensional dynamic systems in receptor theory
Classical structural identifiability methodology applied to low-dimensional dynamic systems in receptor theory
Abstract Mathematical modelling has become a key tool in pharmacological analysis, towards understanding dynamics of cell signalling and quantifying ligand-receptor interactions. Ordinary differential equation (ODE) models in receptor theory may be used to parameterise such interactions using timecourse data, but attention needs to be paid to the theoretical identifiability of …