Overview of model-assisted design for phase I dose-finding trials in oncology
Overview of model-assisted design for phase I dose-finding trials in oncology
Numerous model-based designs for dose-finding have been proposed to improve the phase I trials (e.g., increasing the accuracy to identify the maximum tolerated dose). However, algorithm-based designs (e.g., the 3+3 design) are still dominantly used regardless of relatively poor performance due to the complexity of the implementation of the model-based …