DROID: Dose-Ranging Approach to Optimizing Dose in Oncology Drug Development
DROID: Dose-Ranging Approach to Optimizing Dose in Oncology Drug Development
Abstract In the era of targeted therapy, there has been increasing concern about the development of oncology drugs based on the “more is better” paradigm, developed decades ago for chemotherapy. Recently, the US Food and Drug Administration (FDA) initiated Project Optimus to reform the dose optimization and dose selection paradigm …