Learning to automate cryo-electron microscopy data collection with <i>Ptolemy</i>
Learning to automate cryo-electron microscopy data collection with <i>Ptolemy</i>
Over the past decade, cryo-electron microscopy (cryoEM) has emerged as an important method for determining near-native, near-atomic resolution 3D structures of biological macromolecules. To meet the increasing demand for cryoEM, automated methods that improve throughput and efficiency of microscope operation are needed. Currently, the targeting algorithms provided by most data-collection …