Methods for handling missing data in serially sampled sputum specimens for mycobacterial culture conversion calculation
Methods for handling missing data in serially sampled sputum specimens for mycobacterial culture conversion calculation
Abstract Background The occurrence and timing of mycobacterial culture conversion is used as a proxy for tuberculosis treatment response. When researchers serially sample sputum during tuberculosis studies, contamination or missed visits leads to missing data points. Traditionally, this is managed by ignoring missing data or simple carry-forward techniques. Statistically advanced …