Evaluating the Effect of SARS-CoV-2 Spike Mutations by Causal Inference
Evaluating the Effect of SARS-CoV-2 Spike Mutations by Causal Inference
Abstract Driven by various mutations on the viral Spike protein, diverse variants of SARS-CoV-2 have emerged and prevailed repeatedly, which necessitates the identification of key Spike mutations for fitness enhancement. To address the need, this manuscript formulates a principled framework of causal inference for evaluating Spike mutations. In the context …