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Spatio-temporal Pattern Formation due to Host-Circuit Interplay in Gene Expression Dynamics

Spatio-temporal Pattern Formation due to Host-Circuit Interplay in Gene Expression Dynamics

Abstract Biological systems are majorly dependent on their property of bistability in order to exhibit nongenetic heterogeneity in terms of cellular morphology and physiology. Spatial patterns of phenotypically heterogeneous cells, arising due to underlying bistability, may play significant role in phenomena like biofilm development, adaptation, cell motility etc. While nonlinear …