Statistical inference of the rates of cell proliferation and phenotypic switching in cancer
Statistical inference of the rates of cell proliferation and phenotypic switching in cancer
Abstract Recent evidence suggests that nongenetic (epigenetic) mechanisms play an important role at all stages of cancer evolution. In many cancers, these mechanisms have been observed to induce dynamic switching between two or more cell states, which commonly show differential responses to drug treatments. To understand how these cancers evolve …