Optimal Cancer Evasion in a Dynamic Immune Microenvironment
Optimal Cancer Evasion in a Dynamic Immune Microenvironment
Abstract The failure of cancer treatments, including immunotherapy, continues to be a major obstacle in preventing durable remission. This failure often results from tumor evolution, both genotypic and phenotypic, away from sensitive cell states. Here, we propose a mathematical framework for studying the dynamics of adaptive immune evasion that tracks …