Evaluation of phase I clinical trial designs for combinational agents along with guidance based on simulation studies
Evaluation of phase I clinical trial designs for combinational agents along with guidance based on simulation studies
Combinational therapy that combines two or more therapeutic agents is very common in cancer treatment. Currently, many clinical trials aim to assess feasibility, safety and activity of combinational therapeutics to achieve synergistic response. Dose-finding for combinational agents is considerably more complex than single agent, because only partial order of dose …