A multicompartment mathematical model based on host immunity for dissecting COVID-19 heterogeneity
A multicompartment mathematical model based on host immunity for dissecting COVID-19 heterogeneity
The determinants underlying the heterogeneity of coronavirus disease 2019 (COVID-19) remain to be elucidated. To systemically analyze the immunopathogenesis of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, we built a multicompartment mathematical model based on immunological principles and typical COVID-19-related characteristics. This model integrated the trafficking of immune cells …