Estimating the Proportion of True Null Hypotheses for Multiple Comparisons
Estimating the Proportion of True Null Hypotheses for Multiple Comparisons
Whole genome microarray investigations (e.g. differential expression, differential methylation, ChlP-Chip) provide opportunities to test millions of features in a genome. Traditional multiple comparison procedures such as familywise error rate (FWER) controlling procedures are too conservative. Although false discovery rate (FDR) procedures have been suggested as having greater power, the control …