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ODACH: a one-shot distributed algorithm for Cox model with heterogeneous multi-center data

ODACH: a one-shot distributed algorithm for Cox model with heterogeneous multi-center data

We developed a One-shot Distributed Algorithm for Cox proportional-hazards model to analyze Heterogeneous multi-center time-to-event data (ODACH) circumventing the need for sharing patient-level information across sites. This algorithm implements a surrogate likelihood function to approximate the Cox log-partial likelihood function that is stratified by site using patient-level data from a …