Spatial structure impacts adaptive therapy by shaping intra-tumoral competition
Spatial structure impacts adaptive therapy by shaping intra-tumoral competition
Adaptive therapy aims to tackle cancer drug resistance by leveraging resource competition between drug-sensitive and resistant cells. Here, we present a theoretical study of intra-tumoral competition during adaptive therapy, to investigate under which circumstances it will be superior to aggressive treatment.We develop and analyse a simple, 2-D, on-lattice, agent-based tumour …