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Estimating protection afforded by prior infection in preventing reinfection: Applying the test-negative study design

Estimating protection afforded by prior infection in preventing reinfection: Applying the test-negative study design

Abstract Background The Coronavirus Disease 2019 (COVID-19) pandemic has highlighted an urgent need to use infection testing databases to rapidly estimate effectiveness of prior infection in preventing reinfection ( PE S ) by novel variants of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Methods Mathematical modeling was used to …