Diffusion approximations in population genetics and the rate of Muller’s ratchet
Diffusion approximations in population genetics and the rate of Muller’s ratchet
The Wright-Fisher binomial model of allele frequency change is often approximated by a scaling limit in which selection, mutation and drift all decrease at the same 1/ N rate. This construction restricts the applicability of the resulting “Wright-Fisher diffusion equation” to the weak selection, weak mutation regime of evolution. We …