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Using Social Contact Data to Improve the Overall Effect Estimate of a Cluster-Randomized Influenza Vaccination Program in Senegal

Using Social Contact Data to Improve the Overall Effect Estimate of a Cluster-Randomized Influenza Vaccination Program in Senegal

This study estimates the overall effect of two influenza vaccination programs consecutively administered in a cluster-randomized trial in western Senegal over the course of two influenza seasons from 2009-2011. We apply cutting-edge methodology combining social contact data with infection data to reduce bias in estimation arising from contamination between clusters. …