A DNA-structured mathematical model of cell-cycle progression in cyclic hypoxia
A DNA-structured mathematical model of cell-cycle progression in cyclic hypoxia
Abstract New experimental data have shown how the periodic exposure of cells to low oxygen levels ( i.e. , cyclic hypoxia) impacts their progress through the cell-cycle. Cyclic hypoxia has been detected in tumours and linked to poor prognosis and treatment failure. While fluctuating oxygen environments can be reproduced in …