Ten simple rules for conducting a mendelian randomization study
Ten simple rules for conducting a mendelian randomization study
Mendelian randomization (MR) is an epidemiological technique for estimating causal relationships using observational data, which has become very popular in recent years following publication of a seminal article by Smith and Ebrahim in 2003 [1]. MR is a specific form of “instrumental variables” (IV) analysis (the latter being first invented …