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Discussion on “Improving precision and power in randomized trials for COVID‐19 treatments using covariate adjustment for binary, ordinal, and time‐to‐event outcomes”
Abstract Benkeser et al . present a very informative paper evaluating the efficiency gains of covariate adjustment in settings with binary, ordinal, and time‐to‐event outcomes. The adjustment method focuses on estimating the marginal treatment effect averaged over the covariate distribution in both arms combined. The authors show that covariate adjustment …