Artificial intelligence advances for de novo molecular structure modeling in cryo‐electron microscopy
Artificial intelligence advances for de novo molecular structure modeling in cryo‐electron microscopy
Cryo-electron microscopy (cryo-EM) has become a major experimental technique to determine the structures of large protein complexes and molecular assemblies, as evidenced by the 2017 Nobel Prize. Although cryo-EM has been drastically improved to generate high-resolution three-dimensional (3D) maps that contain detailed structural information about macromolecules, the computational methods for …