Probing the subcellular nanostructure of engineered human cardiomyocytes in 3D tissue
Probing the subcellular nanostructure of engineered human cardiomyocytes in 3D tissue
Abstract The structural and functional maturation of human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) is essential for pharmaceutical testing, disease modeling, and ultimately therapeutic use. Multicellular 3D-tissue platforms have improved the functional maturation of hiPSC-CMs, but probing cardiac contractile properties in a 3D environment remains challenging, especially at depth and …