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Assessing Uncertainty in the Rooting of the SARS-CoV-2 Phylogeny

Assessing Uncertainty in the Rooting of the SARS-CoV-2 Phylogeny

Abstract The rooting of the SARS-CoV-2 phylogeny is important for understanding the origin and early spread of the virus. Previously published phylogenies have used different rootings that do not always provide consistent results. We investigate several different strategies for rooting the SARS-CoV-2 tree and provide measures of statistical uncertainty for …