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Design and analysis of three‐arm parallel cluster randomized trials with small numbers of clusters

Design and analysis of three‐arm parallel cluster randomized trials with small numbers of clusters

In this article, we review and evaluate a number of methods used in the design and analysis of small three‐arm parallel cluster randomized trials. We conduct a simulation‐based study to evaluate restricted randomization methods including covariate‐constrained randomization and a novel method for matched‐group cluster randomization. We also evaluate the appropriate …