Homeorhesis in Waddington's landscape by epigenetic feedback regulation
Homeorhesis in Waddington's landscape by epigenetic feedback regulation
The authors introduce a theoretical model that combines gene expression dynamics with epigenetic modification, which changes the feasibility of expression, i.e., the threshold for expression. By taking into account of a slow positive-feedback process from expression to the threshold level, the paper finds several distinct cell types that are given …