Spatial model predicts dispersal and cell turnover cause reduced intra-tumor heterogeneity
Spatial model predicts dispersal and cell turnover cause reduced intra-tumor heterogeneity
Most cancers in humans are large, measuring centimeters in diameter, composed of many billions of cells. An equivalent mass of normal cells would be highly heterogeneous as a result of the mutations that occur during each cell division. What is remarkable about cancers is their homogeneity - virtually every neoplastic …