Multi-scale coarse-graining for the study of assembly pathways in DNA-brick self-assembly
Multi-scale coarse-graining for the study of assembly pathways in DNA-brick self-assembly
Inspired by recent successes using single-stranded DNA tiles to produce complex structures, we develop a two-step coarse-graining approach that uses detailed thermodynamic calculations with oxDNA, a nucleotide-based model of DNA, to parametrize a coarser kinetic model that can reach the time and length scales needed to study the assembly mechanisms …