Turnover Modulates the Need for a Cost of Resistance in Adaptive Therapy
Turnover Modulates the Need for a Cost of Resistance in Adaptive Therapy
Abstract Adaptive therapy seeks to exploit intratumoral competition to avoid, or at least delay, the emergence of therapy resistance in cancer. Motivated by promising results in prostate cancer, there is growing interest in extending this approach to other neoplasms. As such, it is urgent to understand the characteristics of a …