Single-Particle Cryo-Electron Microscopy: Mathematical Theory, Computational Challenges, and Opportunities
Single-Particle Cryo-Electron Microscopy: Mathematical Theory, Computational Challenges, and Opportunities
In recent years, an abundance of new molecular structures have been elucidated using cryo-electron microscopy (cryo-EM), largely due to advances in hardware technology and data processing techniques. Owing to these exciting new developments, cryo-EM was selected by Nature Methods as the "Method of the Year 2015," and the Nobel Prize …