Spatial structure impacts adaptive therapy by shaping intra-tumoral competition
Spatial structure impacts adaptive therapy by shaping intra-tumoral competition
Abstract (1) Background: Adaptive therapy aims to tackle cancer drug resistance by leveraging intra-tumoral competition between drug-sensitive and resistant cells. Motivated by promising results in prostate cancer there is growing interest in extending this approach to other cancers. Here we present a theoretical study of intra-tumoral competition during adaptive therapy, …