Hybrid E/M phenotype(s) and stemness: a mechanistic connection embedded in network topology
Hybrid E/M phenotype(s) and stemness: a mechanistic connection embedded in network topology
Abstract Metastasis remains an unsolved clinical challenge. Two crucial features of metastasizing cancer cells are a) their ability to dynamically move along the epithelial-hybrid-mesenchymal spectrum and b) their tumor-initiation potential or stemness. With increasing functional characterization of hybrid epithelial/mesenchymal (E/M) phenotypes along the spectrum, recent in vitro and in vivo …