Continual reassessment method with regularization in phase I clinical trials
Continual reassessment method with regularization in phase I clinical trials
Many Phase I trial designs have been developed to improve upon the standard 3+3 design. These designs can be classified as long-memory designs, for example, the continual reassessment method (CRM), and short-memory designs such as the modified toxicity probability interval (mTPI) design. Long-term memory designs use all data but their …