Prefer a chat interface with context about you and your work?
Robustness of signal detection in cryo-electron microscopy via a bi-objective-function approach
The detection of weak signals and selection of single particles from low-contrast micrographs of frozen hydrated biomolecules by cryo-electron microscopy (cryo-EM) represents a major practical bottleneck in cryo-EM data analysis. Template-based particle picking by an objective function using fast local correlation (FLC) allows computational extraction of a large number of …