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The consequences of adjustment, correction and selection in genome-wide association studies used for two-sample Mendelian randomization
ABSTRACT Introduction Genome-wide association studies (GWASs) often adjust for covariates, correct for medication use, or select on medication users. If these summary statistics are used in two-sample Mendelian randomization analyses, estimates may be biased. We used simulations to investigate how GWAS adjustment, correction and selection affects these estimates and performed …