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Minimal transmission in an influenza A (H3N2) human challenge-transmission model within a controlled exposure environment

Minimal transmission in an influenza A (H3N2) human challenge-transmission model within a controlled exposure environment

Uncertainty about the importance of influenza transmission by airborne droplet nuclei generates controversy for infection control. Human challenge-transmission studies have been supported as the most promising approach to fill this knowledge gap. Healthy, seronegative volunteer 'Donors' (n = 52) were randomly selected for intranasal challenge with influenza A/Wisconsin/67/2005 (H3N2). 'Recipients' …